Gastroesophageal reflux disease (GERD) is a condition in which food or liquid travels backwards from the stomach to the esophagus (the tube from the mouth to the stomach). This action can irritate the esophagus, causing heartburn and other symptoms.

Gastroesophageal reflux is a common condition that often occurs without symptoms after meals. In some people, the reflux is related to a problem with the lower esophageal sphincter, a band of muscle fibers that usually closes off the esophagus from the stomach. If this sphincter doesn't close properly, food and liquid can move backward into the esophagus and may cause the symptoms.

The risk factors for reflux include hiatal hernia (a condition in which part of the stomach moves above the diaphragm, which is the muscle that separates the chest and abdominal cavities), pregnancy, and scleroderma.

A number of studies suggest that obesity contributes to gastroesophageal reflux. For instance, the Nurses Health Study found that being overweight or obese significantly increased reflux symptoms in women. (Women who lost weight in the study, meanwhile, had fewer symptoms.)

Heartburn and gastroesophageal reflux can be brought on or worsened by pregnancy and by many different medications. Such drugs include:

• Anticholinergics (e.g. for seasickness)
• Beta blockers for high blood pressure or heart disease
• Bronchodilators for asthma
• Calcium channel blockers for high blood pressure
• Dopamine-active drugs for Parkinson's disease
• Progestin for abnormal menstrual bleeding or birth control
• Sedatives for insomnia or anxiety
• Tricyclic antidepressants

If you suspect that one of your medications may be causing heartburn, talk to your doctor. Never change or stop medication you take regularly without talking to your doctor.

• Belching
• Cough or wheezing
• Difficulty swallowing
• Heartburn
  • Involves a burning pain in the chest (under the breastbone)
  • Increased by bending, stooping, lying down, or eating
  • More frequent or worse at night
  • Relieved by antacids
• Hoarseness or change in voice
• Nausea and vomiting
• Regurgitation of food
• Sore throat
• Vomiting blood

• A barium swallow showing reflux
• A positive Bernstein test for gastric acid reflux
• Continuous esophageal pH monitoring showing reflux
• Endoscopy showing ulceration or inflammation of the esophagus, or Barrett's esophagus
• Esophageal manometry showing abnormal sphincter pressure
• A positive stool guaiac, which may diagnose bleeding from the irritation in the esophagus

General measures include:

• Avoiding alcohol and tobacco
• Avoiding dietary fat, chocolate, caffeine, peppermint, onions, garlic, citrus juices, and tomato products (which may cause lower esophageal pressure)
• Avoiding lying down after meals
• Sleeping with the head of the bed elevated
• Taking medication with plenty of water
• Weight reduction

Medications that alleviate symptoms include:

• Over-the-counter antacids after meals and at bedtime, although they do not last very long
• Histamine H2 receptor blockers, mostly for milder symptoms
• Promotility agents
• Proton pump inhibitors, which may take up to four days to relieve symptoms

The majority of people respond to nonsurgical measures, with lifestyle changes and medications. However, many patients need to continue to take drugs to control their symptoms.

• Barrett's esophagus (a change in the lining of the esophagus that can increase the risk of cancer)
• Bronchospasm (irritation and resulting spasm of airways due to acid)
• Chronic pulmonary disease
• Esophageal ulcer
• Hoarseness
• Inflammation of the esophagus
• Stricture (a narrowing of the esophagus due to scarring from the inflammation)

Call your health care provider if symptoms worsen or do not improve with lifestyle changes or medication.

Also call for any of the following symptoms:

• Bleeding
• Choking (coughing, shortness of breath)
• Early satiety (feeling filled up quickly when eating)
• Frequent vomiting
• Hoarseness
• Loss of appetite
• Trouble swallowing (dysphagia) or pain with swallowing (odynophagia)
• Weight loss

• Heartburn prevention techniques
• Looking at the esophagus with an endoscope and obtaining a sample of esophagus tissue for examination esophagoscopy with biopsy) may be recommended to diagnose Barrett's esophagus.
• Follow-up endoscopy to look for dysplasia or cancer is often advised.

Wang, KK, Sampliner, R E. Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus. Am J Gastroenterol. 2008;103(3):788-97.

Khan, M, Santana, J, Donnellan, C, Preston, C, Moayyedi, P. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database Syst Rev(2). 2007;CD003244.

Wilson, J F. In the clinic. Gastroesophageal reflux disease. Ann Intern Med. 2008;149(3): ITC2-1-15; quiz ITC2-16