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Progressive multifocal leukoencephalopathy

Contents of this page:

Illustrations

Gray and white matter of the brain
Gray and white matter of the brain
Leukoencephalopathy
Leukoencephalopathy

Alternative Names    Return to top

PML

Definition    Return to top

Progressive multifocal leukoencephalopathy (PML) is a rare disorder that damages the material (myelin) that covers and protects nerves in the white matter of the brain.

Causes    Return to top

The JC virus (JCV) causes PML. This virus is found in a lot of people, but usually does not cause symptoms. However, it triggers PML in people who have poor immune function (immunocompromised).

The disease occurs in 4% of adults with AIDS.

Symptoms    Return to top

Exams and Tests    Return to top

Tests may include:

Treatment    Return to top

Treatment consists of antiviral drugs and other medications.

Outlook (Prognosis)    Return to top

PML is a very serious condition. Talk to your doctor about care decisions.

References    Return to top

Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases. 5th ed. London: Churchill Livingstone; 2000:1856-1861.

Cohen J, Powderly WG. Infectious Diseases. 2nd ed. New York, NY: Elsevier; 2004:2046.

Update Date: 2/13/2008

Updated by: Luc Jasmin, MD, PhD, Departments of Anatomy & Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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